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In oncology, one strategy used in the development of some anticancer agents (especially for solid tumors) has been to demonstrate an objective response of meaningful magnitude and duration for accelerated approval in a refractory population. d(c)0 dx d[cf1(x)]cdf1(x) dx dx d[f1(x)f2(x)]df1(x)df2(x) dx dxdx d [f1(x) f2(x)] f1(x) d f2(x) f2(x) d f1(x) dx dx dx d f1(x) f2(x)(ddx)f1(x) f1(x)(ddx)f2(x) e.
Tensorial morphological gradient (TMG) x E, where is the supremum of a subset, B E is a structuring element centered at the origin of E, dn represents any of the similarity measures pre- sented in DTI literature [23,24], Ty is the tensor that represents the diffusion in y, and Tz is the tensor that represents the diffusion in z (y and z are in the neighborhood of x, defined by E).
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